I'm pretty sure I've seen an issue like that before.
Check in the bios, if Allocate IRQ to USB is enabled
also in bios, set USB keyboard and mouse support to BIOS, rather than OS.
I had a PC that wouldn't post when a certain ps/2 keyboard and mouse were plugged in, but it would if a different set were plugged in. If I plugged them in after windows was up, they would work fine, but the system would crash on shutdown!