Both involve writing on the board, though I guess you could write on a sticker and place it on the board. Pandemic adds stickers, but you can probably remove them once done.
If your question is can you replay it, it's very difficult. Pandemic for instance involves opening boxes, sticking rules into the rulebook, board and player cards. It would be a lot of hassle to get around this, especially with having to open stickers to know the new rules.