Yup, I still get it with every driver set, well not seen if I get it on 10.3 or not.
Disable powerplay and no issues with video playback crashes, flickering on second screen nor the big mouse pointer.... i really don't know why the last one occurs, its truly bizarre.
Either way gpu clock tool from techreport's site, on booting just set your default 3d clocks, or whatever you want, 400/900 seems to work for some people, I still got the flickering by not mouse/crashing at that speed but everything works fine at 550/1000.
I now use MSI afterburner to set those clocks but a lower voltage(which is where most of the power saving from powerplay comes from), because it doesn't get unstable for me under doing basic things, largely because its not under full load.
I have a few profiles set up as you can save 5 and change them at a touch of a button. I have 777/1000 with lower voltage for windows use, 900/1225 and 1.2v for most games and for and it does fine at 950/1250/1.25v when my rooms not baking hot to start with, all without getting silly loud.
Disabling powerplay 100% certainly fixes the big mouse and video playback crashing, as others have said its probably an issue with mobo/bios, but running an older DFI bios that I haven't seen an update for in a long time.