Microphone audio issues with Discord/TS and Shadowplay

[Musty Chapstick]

Over the past couple of months I've been having weird audio issues. My set up is as follows

Focusrite Scarlett Solo USB audio interface
Audio Technica AT2020 XLR mic
3m XLR Mic cable

When playing a certain game (DayZ) with friends they say my mic audio goes static sounding this is the same for Discord and Team Speak. Also when recording game footage my mic audio is really garbled and digitized, however when streaming on twitch my mic audio is perfect.

Can anyone point me in a direction to sort this out?

Clip of said garbled shadowplay footage (ive since fixed the left channel audio only problem) https://streamable.com/jpc45z

 

[Musty Chapstick]

Thanks for the response Chaz,

Im using about 60-70% CPU when Streaming and gaming and about 50% of my 32Gb of RAM.
I do have an external HDD connected via USB (now disconnected)

I've also done the optimizations on the Focusrite forum. I'll report back with my findings.

Cheers