As good as NVME drives are they can be a pain when having to remove as a GPU etc can be covering it (GPU covers mine in this system).Not sure if you can disable nvme in the bios but I'll a look.
If I have to remove the drive it will be a good excuse to deep clean the gpu etc.
I've only ever had 1 drive on my main rig for some time so no need to disconnect any other drives. At least with sata drives you just disconnected the cable so was easily done