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It's generally left on at the wall, don't often switch it off at the outlet. It was left on at the whall whilst I was away. Other times I have switched if off for a few days and it's been fine.
It's been ok since, but it's only been a couple of days. Card was securely clipped into pcie slot (had to use the clamp/lever at the end of the slot to release etc, and three screws securing it to backplate were snug) so unless something board side I don't think it came out of the slot at all. I'm also using the support bracket that came with it so don't think it's card sag either.
Are you using the supplied support bracket ?
