Hi, I have been battling with an unstable PC for a while now and I was hoping the experts over here at OCUK might be able to help 
I'll start by describing the problem, and go on to the specs and all the things I've tried which is directing me to a motherboard issue.
The PC will crash under load, usually in fairly graphics intensive games - could be Civ V, BF4, Saints Row, Endless space. It's a hard crash - screen goes black and requires a hard reboot. Can crash a few minutes in or an hour in. Seems stable in desktop conditions.
Specs:
Motherboard: GA-Z77-D3H (rev. 1.0); latest bios
CPU: Intel ivybridge i5 3570K
RAM: Corsair dual channel 2x4gb 1600MHz
PSU: Corsair CXM 750W
Graphics: Radeon HD 7850
Others: 250GB SSD, 1TB HDD, DVD drive
I haven't done any overclocking.
Things I've tried:
The most obvious thing was potential overheating. I've been running temp checks on both GPU and CPU, neither are problematic and will crash even when they are fairly low, when a game has only been running a few mins. Tried with side off case in the middle of winter etc. I just don't think thats it.
Software: Reinstall windows 7, and now I've installed Win 10. Try about 6 different ATI drivers (currently on the latest). Tried many different BIOS versions. Updated all hardware drivers. I think I've covered all bases here.
Memory: Tried memory in any combo of slots, with one or two sticks. Unless both sticks are iffy, I think its OK.
PSU: Upgraded to from an older 550W supply to the current 750W supply. No change.
Graphics:
This is the sticking point. the HD 7850 causes a hard crash, but I've tried two brand new 280Xs (gigabyte and MSI) and both showed a lot of artifacting, even after short periods. The machine did not hard crash with these cards. These cards are designed to run hot but I struggle to believe both would artifact in open case, free airflow conditions. I believe they also have a thermal throttle if they start overheating.
CPU: This (with the mobo) is the only thing I haven't been able to check. I've reseated it and re-pasted it with the heatsink. Temps are fine under 80C under load (stock)
BIOS:
I have tried SO many settings and versions as to be ridiculous now. Stuff from various threads, memory timings, CPU states, god knows what else. Even tried disabling onboard sound.
Others:
The SSD is new(ish). I've had windows on both HDD and the SSD, no difference. I've of course reseated everything, and there is minimal dust in the case.
So my question is: If I have ruled out all these possibilities (tell me if you don't think I have), is it possible to do any tests to see if there is an issue with the mobo? Could it indeed be causing the crash, and the artifacting I mention in the 280X cards?
Thank you for taking the time to read through this,
Col
NOTE: I no longer have access to the 280X cards.

I'll start by describing the problem, and go on to the specs and all the things I've tried which is directing me to a motherboard issue.
The PC will crash under load, usually in fairly graphics intensive games - could be Civ V, BF4, Saints Row, Endless space. It's a hard crash - screen goes black and requires a hard reboot. Can crash a few minutes in or an hour in. Seems stable in desktop conditions.
Specs:
Motherboard: GA-Z77-D3H (rev. 1.0); latest bios
CPU: Intel ivybridge i5 3570K
RAM: Corsair dual channel 2x4gb 1600MHz
PSU: Corsair CXM 750W
Graphics: Radeon HD 7850
Others: 250GB SSD, 1TB HDD, DVD drive
I haven't done any overclocking.
Things I've tried:
The most obvious thing was potential overheating. I've been running temp checks on both GPU and CPU, neither are problematic and will crash even when they are fairly low, when a game has only been running a few mins. Tried with side off case in the middle of winter etc. I just don't think thats it.
Software: Reinstall windows 7, and now I've installed Win 10. Try about 6 different ATI drivers (currently on the latest). Tried many different BIOS versions. Updated all hardware drivers. I think I've covered all bases here.
Memory: Tried memory in any combo of slots, with one or two sticks. Unless both sticks are iffy, I think its OK.
PSU: Upgraded to from an older 550W supply to the current 750W supply. No change.
Graphics:
This is the sticking point. the HD 7850 causes a hard crash, but I've tried two brand new 280Xs (gigabyte and MSI) and both showed a lot of artifacting, even after short periods. The machine did not hard crash with these cards. These cards are designed to run hot but I struggle to believe both would artifact in open case, free airflow conditions. I believe they also have a thermal throttle if they start overheating.
CPU: This (with the mobo) is the only thing I haven't been able to check. I've reseated it and re-pasted it with the heatsink. Temps are fine under 80C under load (stock)
BIOS:
I have tried SO many settings and versions as to be ridiculous now. Stuff from various threads, memory timings, CPU states, god knows what else. Even tried disabling onboard sound.
Others:
The SSD is new(ish). I've had windows on both HDD and the SSD, no difference. I've of course reseated everything, and there is minimal dust in the case.
So my question is: If I have ruled out all these possibilities (tell me if you don't think I have), is it possible to do any tests to see if there is an issue with the mobo? Could it indeed be causing the crash, and the artifacting I mention in the 280X cards?
Thank you for taking the time to read through this,
Col
NOTE: I no longer have access to the 280X cards.