Are you using soft tubing or hardline and what sort of res are you using? If you are using soft and have a tube res such that you can temporarily take the pump/res off its mount so you can hold it vertical, you can then lay the case flat on its side, i.e. with the mobo pointing to the sky, and if you plumb it so the inlet ports to the rads are bottom-most, and the outlet ports top-most in this orientation on the side, then the air in the rads will naturally rise towards the outlet and back into the res, which you are holding vertical, and thus bleed out easily. This is method is either borked and made harder if you are using hardline or have a bay res of some sort, as you can't easily make it so the air coming back to the res will find its way out. One of he reasons why I personally will never go hardline.