The entire system should be sealed assuming you have a Lid on your res?
the EK kits have rubber o-rings on the lids so these are watertight, im assuming here but surely any good res will be filly sealed.
Id think you would be fine, you may end up with some bubbles in your res however if the water is splashing around but would disappear quickly once restarted as the pressure will force them out.
Essentially, no you should be fine.