Yes my wife system is a MSI 450 tomohawk max, and when i upgrade my own rig very recently i plumped for the MSI MAG x570 tomahawk
The is a nifty 2 layer nvme drive bay on the 450 MAX, it supports all current chips and likely 4000 series later, but if you are building pair a 3600 with a 450 MAX and decent ram and you've a system that kick whatever it needs to for a right while. Your level of output will only be helped/hindered by whichever GFX you aim for to match with it.
The board is about 120, a ryzen 3600 can be picked up for 155-160, the stock cooler is perfecly sufficient. Match in some decent Ram, and all you'll need is to decide what level of GFX card you wish to go for.