You can try the 8.10betas if you want manual fan control in the control center, or RivaTuner 2.11 with this
guide. I recommend the Riva method because it's more flexible and will try and keep your target temps.
If you mean 3D settings, I find 4X edge-detect AA, adaptive AA, high mipmap and advanced Cat AI to work fine in Warhead and other games @ 1920x1200. Up until the end boss, of course...
BTW, I idle at 48C and load 74C currently. I was previously using 35% fan and 45% fan respectively but now with RivaTuner managing it the noise actually goes down a lot during games. It's very quick to react to changes in temps.