Is that anywhere near Kathmandu?
I am also having problems with audio and running 2 GTX 260's in SLI.
When both cards are installed and the onboard audio is enabled in the BIOS, I get sound popping and sound loops after playing games for a short time. If I ignore it for long enough it goes away sometimes.
If I disable the onboard audio and use USB audio, then the display driver isn't loaded after Windows start up and it's as if I am installing both graphics cards for the first time. If I reinstall the display driver, SLI is detected and all is well apart from the audio popping. But as soon as the system is powered down and then restarted the display drivers don't start with Windows and I have to reinstall them again. If I restart and re enable the onboard audio in the BIOS, then the display driver loads normally but I still get the audio problems.
I've tried the latest drivers for both the onboard audio and the graphics cards, but nothing works. I also reseated both graphics cards.
I have since removed one of the GTX 260's and I the audio is fine, no popping or sound loops.
Motherboard is Gigabyte GA-X58A-UD3R, with Realtek ALC889 onboard audio.
Windows 7 64Bit Home Premium, fully upto date.