I've put 2x280 rads on top of the case, free to move, so whenever i fill my system i just rotate rads so that end ports point up and all the air in the system goes straight into the res. Not for everybody. If you have mounted your rads in the case i'd say a fill port at the top most part of the loop would be a good idea. Also it depends on the order of the loop, my rads empty into res/pump combo, so all the air doesnt have to travel through the system to get to reservoir...