I can't think of any reason why you would??? I've you have that many devices for say storage then you should be looking a switch or NAS anyway.
Technically, each controller allows up to a maximum of 127 devices each sharing the half duplex 480M/bps bandwidth of USB 2 although this has increased top 5 and 10 M/bps for USB 3 and USB 3.1 respectively.
Although the speed is very much welcome i've never had more than half a dozen devices connected at one time. Mouse/Keyboard/Printer direct to motherboard then hot swapable mobile phone/External backup drive/Xbox controller into the FP as and when needed.. that's it.
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