Just fine, had my 1080 paired with a 1440p 144hz display for many years. Newer titles need settings on medium/high but older stuff will run high/ultra quite happily.
yes - that's what I run - 1080GTX with a Dell S2721DGF (1440p 165Hz)
Games like World of Warships / Civ 6 run easily at 144Hz at max settings , however more modern games may need the settings reducing or accepting lower frame rates . The monitor you've linked is Gsync compatible so you should be fine
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