You could always change the core affinity using either task manager or a third party program (i think there is one called FAH affinity changer, although i am not sure...). You could then tell the smp client to only address cores x, y and z, and address the gpu to the other core. If the two clients are fighting one another for cpu time, then you may need to set one to have a slightly higher priority in the config menu (in my experience, the gpu client does not use much cpu power under vista, but it does seem to vary from person to person). In mattus' screenshot above you can see there is the option for idle, or low (at the top). Set one to idle and one to low (gfx to low i imagine would be best), and they should resolve their differences and get along... This is certainly easier than changing core affinity.