I wouldn’t run straight to bosses, get as much as you can from the area/s you can access before you fight them.
best tips I can give
Unlock weapon skills, guns can have up to 3 once you’ve unlocked them.
Collecting Silphium at full health, will help expand your health bar.
Most malfunctions aren’t too bad and are usually easy to clear (collect 1 artefact, kill 15 monsters, collect 150 obolites). With that in mind, open the tainted chests.
regarding obolites, destroy plants for extra and statues with gold eyes.
Use the reclaimer if you find one, it takes some health but you get a good item usually.