It won't affect your CPU overclocking, but it can lead to a small (and usually negligible) reduction in memory performance as the BIOS will set the timings on each channel to those of the slowest module.actually, from what you are saying, I could throw in my original 3x2gb ram into the three unused slots and run them as well .. but is that more or less efficient than running dedicated triple channel ram (total 12gb) compared to (total 18gb) of whatever channel it will make it with all slots full??? Will that adversely affect the overclock?