Cable management is only awkward if you have a lot of stuff inside the computer, (dual graphics cards, multiple hard discs etc) as there isn't a huge amount of space for cable routing behind the back panel. It can be done, with some time, but it just needs that time and proper routing.
The dust filters are easy to change, you pop the side off, pull them out and give them a hoover. Considering how effective they genuinely are, I don't think that is too much trouble. (My PC sits on a laminate floor in a household with pets, it stays remarkably clean inside though!)
I currently have a Sapphire 7970 OC edition, the cooler on this works just fine and my case temperatures remain excellent.
It's a quiet case, cools well and looks nice. It took me many cases to eventually settle on this one, I always wanted something new, but I have settled on this and couldn't be happier. I wouldn't recommend it for water cooling even if I am tempted by some of the 180 rads that are turning up!