If you are using all 6 slots yes it will be harder to achieve a max over-clock. But for normal 24/7 use you will hardly notice any difference. You might have to tweak a voltage here and there to provide for the added strain on the CPU IMC. As you know the Internal Memory Controller will need to work a bit harder now that all 6 slots are populated.
Yeah that makes sense. Had my stable OC at 3.8 but don't push this much usage even with 8 VMs, needed more memory as this balloons with the more VMs you have
I have my i7 950 on an ASUS rampage 3 with 12gb of ram sat happily at 4.2Ghz, just needed a bit more juice on the DRAM 1.66v so minimal difference really
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