PC doesn't like to boot..

[sorn21]

I know you are most likely sick of these threads, but I need a little bit of help..

Specs are as follows;

Q6600,
ASUS P5Q3 Deluxe,
6GB OCZ DDR3 1866mhz,
HD4870 1GB,
F3 500GB Boot drive,
WD 73GB Raptor,
2x F1 1TB,
Corsair HX620

This has been a PITA recently, I'm getting a regular;
"Boot Manager Missing ctrl + alt + delete to restart"

From this point I have to reformat as the previous Windows installation seems to have gone awry.

I've also noticed that the HDD tends to Lock up, HDD indicator light is on - HDD isn't spinning and the system isn't responding - What can cause this?
This has happened on multiple drives, so I'm confident the HDD isn't at fault.

The MB is a RMA replacement, as is the Q6600.

I recently took apart the full system and rebuilt, this seemed to have a positive effect as I had no problems for about a week, then it froze and I'm faced with the same situation!

How can I alienate the fault?! It's driving me mad

 

[sorn21]

I've tried several discs and they all do the same.
But I'm willing to have a look, how do I check SMART in bios?

 

[sorn21]

There will be an option in your BIOS to turn on "SMART monitoring" for your hard disks.
Once this is enabled, the SMART status will be displayed when your PC boots up.

Ah, that could be a problem, as the PC isn't booting

 

[sorn21]

My bad, yes I get splash and it will detect devices, then Boot Manager...

 

[sorn21]

Ok will do this when I get home, I'm still at work.

Any other suggestions so I have a few things to try and work out what's causing this?

I'd like to try and get it fixed Tonight!!