Depends on the speakers. If they are the same make/model, then yes; if no, then it depends on their Ohm and sensitivity rating.
Also bear in mind, that driving two sets of speakers is double the load for the amp. If an amp is turned up to 50% volume for desirable listening level with one set of speakers, then by using two sets of speakers at the same time, if they are of similar spec, you can't achieve the same level of volume for both sets of speaker as you could when using the one set. That would mean maximum volume which would lead to clipping and distortion, which in turn would eventually damage the speakers. For powering two sets of speakers, you'd need an amp with enough headroom, that you can easily reach the desired volume level without stressing the amp.