Depends, if you have a negative pressure setup, like mine, you will suck in more dust but you will also get more consistant airflow through the case.
If you filter the air coming in and have a well built case then dust isn't really that much of an issue, its all down to trail and error, both positive and negative pressure setups have up and downsides.
I do suffer from blocked up air intakes every few months but with silent intake and outake fans combined with a very large case i want the entire inside of the case to be at a consistent temp.