Lol eell your case is certainly big enough to handle some enormous rads. The question is will your pump unit handle it.
Large rads with more fans means you get a better rate of cooling at lower fan speeds which in turn gives you a much quieter pc. a lot of it dependd on your fan choices and what speed you ppan on running them. You can do high speed for extra performance but you'll get more noise. Low speed for lesser performance and next to no noise, and then there's always the balanced approach.
What do you plan to cool, and what kind of overclock if any are you hoping to achieve?