most ram disk programs will tell you what to use, some games are specific but most use temp folders / files, so moving your temp folder for a start will speed up almost every app/program and game you use.
doing a google search for a certain game or app/program gives good results, or use the ram disk program running it the backgroun to tell you what's being used the most etc, sometimes it's only large texture files or certain large files than even need putting on the ram disk, and that speeds up loading or waiting times, instead of seeing the egg timer of doom, it goes on then back to playing, so no waiting at all, but it does depend on what game and how it works etc, anything that's over a certain file size works a lot faster on ram drives, or any file that's accessed a lot. if you find a folder that's called data etc, moving that or intro's cut scene's or movies etc are also instant. but many types of files / folders and programs can be moved or installed that way, or the whole game etc, as it only need's to save on the ram disk, then before you close down, move the saves to your sdd, this is what i do the most, install the whole game to a ram disk, then save the image so as to only install the game once, can make new images as updates come out etc, all saves are instant to the ram disk, then make a backup to your sdd in a folder called well i call games saves, then when i re load the image, which is instant for some and still loads quicker for other games on a standard load time, just re add the saves and play, seems to be a bit of messing about but most big games are well worth it for the gains, but not all work that way, some you still need the game installed on your sdd and just cache some data only
if you use let say steam a lot, all data is in one folder, and each game install has it own settings etc, so can easy be moved onto a ramdisk
Dataram RAMDisk is freeware for personal use (up to 4 GB disk size). Disks larger than 4 GB require registration and a license, i've tried many types of programs, all upto yet have worked well, remember you can have as many drives as you have letters left 26 is max i think

if you can get a board with that much memory in it
some useless facts for you, the biggest ram drive in the world is owned by the USA Government and stands at 2.5TB in size in solid state memory and cost in 2007 4.7million dollars but they did get a discount but didn't print how much

the system which is made up from 40 RamSan 320 units to make one or many multiply drives
for speed nerds,
A RamSan 320 unit holds up to 64GB of RAM in a 3U rack unit. The US government order is housed in three full height rack units. There are over 320 2Gbit/s Fibre Channel ports and the aggregate I/O rate is 36Gbit/s
the ram disk works with a 100TB SDD for back up storage and is used for database use only.