I have tried them all, Norton, which I hated. Kaspersky, AVG, Avast, Macafee which is even worse.
The one that wins my vote however is Avast... it has a nice user interface, light on resources, updates nice and easy, I actually like the voice talking to me.
Macafee and Norton are by far the worst, both charge silly money and bloat everything.
With regards to anti-spyware, I believe Avast has the built in now aswell, don't hold me to that though and if running vista or 7... Windows defender isn't all that bad, not the greatest but it's already there so why not utilize it.