I used to be seriously into registry cleaning and keeping things really shipshape etc, but I sorta realised after a while - what's the point in cleaning 100 or 200 keys out of a database that is millions of keys in size? In the years of me using jv16 PowerTools I have never noticed any difference after it cleaning maybe 600+ keys in my registry.
What made me really aware of this is the fact that I've run a couple of aggressive cleaners on other machines in the last year and they've just buggered the machines to the point that they no longer boot, not even in safe mode. I just thought, was removing those few keys ever remotely worth the hassle of bringing these machines back to life. That's only two cases, but anyway, what I mean is that it makes no real difference compared to cleaning out silly startup programs like Adobe Reader startup accelerator, ituneshelper, quicktime task, realsched, isuspm, all those standard things. That's the only real benefit you'll ever see. Removing a few hundred other keys won't make any difference especially these days with such high-spec hardware.