Registry entry keeps returning after deletion

[singist]

Not sure where to post this but .....

I have just cleaned a mates computer of something like 30 viri and malware etc but I keep getting one registry entry returning after it's been deleted; I wondered if any of you clever people might know how to dig the little bugger out? most things that I can find on the net just reccommend some antispyware or another; I've always used Search and Destroy (free) and found it to be very good but this reg entry keeps returning; where from?

Windows xp home with SP2, System resore turned off.
Spybot Search & Destroy and various other cleaning prog's.

All clean except for this reg entry: Zlob.Downloader.vcd

It is located here: HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\VideoPlugin

I can delete manually or use the prog' but it returns on reboot.

Any help would be gratefully received.

 

[Raumarik]

Have you tried installing Adaware with the "teatimer" option on? That monitors anything adding registry entries and asks you to confirm them - this might help you track down the problem. I think you can tell it to "remember this" and it'll simply never allow that setting to be added.

Alternatively Mike Lin's Startup monitor is handy too:
http://www.mlin.net/StartupMonitor.shtml

Make sure any OS updates are applied, completely up to date as well as the latest version/patch of Internet explorer - it could well be downloading it.