Rosetta appeal

[Pumpkinstew]

Rosetta@home are appealing for extra crunchiness between May and August to try and win something called CASP7.

More info in the newsletter.

Will F@H be having a bash at this too do you think?

 

[WillLack]

Too busy doing Climate prediction - I wonder how much damage I do doing 24/7?

 

[BillytheImpaler]

Damage?

 

[rich99million]

Damage?

damage to the climate i'm guessing


as for CASP all I've found so far on the folding forums was a very old post relating to the CASP5 competition...

CASP is all for structure prediction. This has really nothing to do with things like Alzheimer's, Mad Cow, etc. These diseases are caused by protein misfolding.

Thus, unlike CASP, we are trying to understand something bigger -- not just what is the final shape, but *how* proteins reach the final shape. This is really the critical piece of info for tackling protein folding related disease.

With that said, we actually have discovered a new way to use F@H-like data for structure prediction. While that's not our primary goal, this work has been precirculated to our colleagues running CASP and they have used the info in their methods. Our paper describing this new method should be coming out in Journal of Molecular Biology pretty soon (was recently accepted).

Vijay

if it's a similar deal each year then I assume the same is still true

 

[Pumpkinstew]

Surely to reach an accurate prediction of the final shape of a protein a project would need to accurately model *how* the protein folds?

Not being knowledgeable in the ways of biochemistry I may be missing some subtleties in the statement by Vijay that Rich posted.