You would have a lot of work on your hands getting it going.
People have put 260/280's into Shuttle P2's but the gfx card shroud covers the motherboard 4 pin aux power. You either have to cut the shroud of the gfx card or make a new right angled aux lead. Neither are easy.
Also the SP35 only has a 400w psu, how much power your OCed quad and 280 on load need?
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