Sidebar in wordpress

I couldn't give you an authoritative answer, but seeing as so much of the layout is governed by the CSS, I'd say it was perfectly possible, yes :)
 
You can do anything that's possible with CSS so the answer is yes.
Not sure why you'd want a full width blog though. Text is most easily read at a specific width. I can't recall the exact number of characters but it's around 500px. Anything considerably wider becomes more difficult to follow.
 
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