The Casualty theme music was composed by Ken Freeman, who also composed the theme for sister show, Holby City. The closing music was traditionally quite different to the opening theme, although in recent years there have been few differences. In 2000 the garage duo Oxide & Neutrino sampled the theme tune in the song 'Bound 4 Da Reload (Casualty)', which got to number one in May. Different variations of the theme music have been introduced throughout the show’s history. The longest running was the original theme, which ran for fifteen years between 1986 and 2001. 2001 to 2006 saw a new, ‘poppier’ version of the theme, replaced between 2006 and 2007 by a theme more akin with the original, again composed by Ken Freeman. However, as of the start of the 22nd series, the 2001-2006 theme is once more being used.
There have been nine different variations of the opening titles and closing credits since the show’s inception. In 2001 the show’s characters have appeared in the opening titles, in place of previous generic hospital environment shots. However from 2002 onwards, generic shots were used again, with that theme lasting for four years until it was replaced.