spec me a prank on pc's

Attach a second USB mouse and control it with your foot.

I did this a while ago to the guy sitting next to me. He totally freaked out. Other people around us knew what was going on and when they started to laugh, he blamed them.

All the while I was sat right next to him clicking things and moving my arm around right under his nose.
 
Every 10 minutes eject his cd/dvd drive remotely :D

Played havoc with that one in my previous workplace. My colleague actually thought he had a virus because of it. He even disabled the drive, but I promptly reenabled it and carried on doing it lol

Had to tell him in the end because I couldnt contain my laughter anymore.
 
If he is using it to teach, then you can replace windows sounds, eventually error sounds will 'bong' and if this sound is replaced with a harry and sally type noise, occurring randomly from machines around the room with no one able to explain, it'll cause great alarm :)
 
A while ago a work colleague played a prank on another work colleague. He set up a rule within Outlook to run shutdown.exe everytime a mail is received.

Took him a while to figure out what was going on!
 
As people have said setting the wallpaper to be a screenshot of the desktop is epic. Dont forget to hide the start bar too :)

An amateur one that is really quick is putting sticky tape under the mouse so it doesn't work.

Haha - find and replace happened to me at uni.. my housemate changed the words and and or in my dissertation to words for genitals. Loverly!
 
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