The harmony ultimate remote control is brilliant. IR, RF and Bluetooth courtesy of the included hub. It will control pretty much anything you can stick under a to as well as the tv.
I wouldn't go back to normal remotes after using one harmony or another over the past half decade.
Just remember it is focuses on activities and not devices, so when you press watch a bluray it will control the Tv, the bluray player and the amp, turning them all on and go the correct input. Volume buttons will do amp, play pause etc will do bluray commands. Change to watch tv and channel buttons are for tv, volume will be amp or tv depending on which you tel it you use in this activity.
End of night press off and everything turns off.
Edit.
My current activities are
TiVo - Virgin Media
PS3 - via an adapter as I have the older touch model (no hub)
Roku
XBox One
Smart Hub
Using the following devices
Samsung tv
Sony amp
TiVo
PS3
Roku
Xbox one
Considering adding a hub to give ps4 and wii control as well in the future.