ive been overclocking with cool'n'quiet enabled since the dawn of s939 - i did a hug post with graphs and everything a while ago...
the only time these systems cause any real grief is when your cpu has a very bad clocking profile of a abnormally high voltage floor. - eg, cpu needs a huge jump in voltage for one of the step-jumps in speed or the cpu needs more voltage to run the lowest speed than is default for the cpu.
both of these are easy to fix:
either using bios (if you have suitable options) or a tool such as rmclock:
adjust bios voltage settings to use the maximum "+xx%" you can combined with reduced "1.xxv" to give desired final voltage. this has the effect of raising the votlage at all the step levels by xx% rather than just booting up the final step voltage a lot and each other step by proportianally less - with the idle voltage staying unchanged.
(not all bios let you do this, some do it invisibly)
the idle voltage is especially important: default fsb = 266say, and min multi = 5. = 1333mhz normal idle speed at idle volts (say 1v) you overclock to 450*9= 4050mhz load with 1.5v - your idle is now 2250mhz @1v - just 150mhz down from stock frequency but .3v below stock! - using +15% voltage gives you 1.15v idle (only 0.15v down vs .3) and 1.495v load.
the other option is using rmclock to alter the voltage for every multiplier step.
you can also use rmclock to quickly lock out speedstep and hold cpu at max
or min speed - if you lock at max and pc is unstable oc'ed its nothing todo with speedstep.
another thing to point out: this works perfectly for me with amd rig per sig, my ram speed alters from 583mhz to 243mhz and a variety of speeds in between while cpu is ramping up and down. with 4 sticks. due to on-die mem controler - these technologys are well engineered and save you a lot of cash, and noise when you want to watch a film
hopefully the above will help you, or someone.