Turn the speakers off and see if it still occurs.
I had a friends machine do this, i think eventually we discovered it was some voltage regulators on the board. Plugging in a usb hub fixed it, it was being caused by any usb device drawing power from the usb.
This is not a disguised pimp, but folding also fixed it by putting the cpu under load, which presumably also put the buzzing power circuitry under load and stopped it buzzing.
We changed everything including the psu, harddisks etc and came to the conclusion it must be something on the board.
Its possible that your speakers are amplifying it, on my friends machine it was so loud it didn't need the speakers to amplify it for it to be annoying.