No real 'optimizers' as such. You could try Comodo System Cleaner or Ccleaner to rid your system of junk files [though personally I'd leave the registry alone], and defragment using Jkdefrag.
Also, use Winpatrol to reduce the amount of crud you have running at system startup. All these items are freeware, and frankly I doubt if there is any payware that could do any more for you.....