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Thermaltake Core V21

No it wouldnt, you need an mATX board to fit into that case
however the GPU would fit fine..

that case can hold a 350mm long card and the one you shown is 325mm
 
that would fit yeah

just make sure you have enough space for it as it is quite wide

-Dimension (H x W x D): 463 x 371 x 540 mm (18.2 x 14.6 x 21.3 inch)
 
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