As long as you have your /home on a different partition to the / then just reinstall over it.
If you keep your /home intact then you can happily chop and change any version of Linux without actually losing a thing... Well maybe the odd background or theme perhaps, but apart from that, Im sure that everything is kept as-is.
For example, I have gone from Ubuntu 9.10 ( 64Bit ) to Mint 9 ( 32Bit ) to Debian 5.0.3 ( 32Bit ) and then to Kubuntu and back to Ubuntu, both 10.4-64Bit then to Mandriva Gnome ( 32Bit ) and then to Debian 5.0.5-64Bit all without losing a thing other than the themes and thats because I mostly use the Emerald themer with Compiz-Fusion, and they're not standard are they?