I saw this video over at the Back|Track site which shows just how easily a Vista box can be compromised. Admittedly, you need physical access, so the machine could be hacked any number of ways, but I was amazed that Microsoft's flagship OS is vulnerable in such a basic way... renaming cmd.exe as UtilMan.exe 
http://www.offensive-security.com/movies/vistahack/vistahack.html

http://www.offensive-security.com/movies/vistahack/vistahack.html