Unless you want to put up with a load of British geezers on the sauce, try and avoid going to Prague over the weekends.
However, it you don't mind that then you should enjoy.
Myself and 2 friends went to Prague 2 years ago. Had a great time, loads to see and do
This year, we are thinking of going to Hamburg or Berlin. I have to get a green card off the bride though as I have already been to:- Israel and Barcalona this year with Estonia and Moscow coming later on in the year.
Barca is another good place to go, but watch for pickpockets. They are rife down Las Ramblas way.
If you do go, try and get a visit to the Camp Nou in.
How about Tallin? Few people I know have been and say that it is a great place to visit. Cheap as chips as well, apparently.