Which of these AV/Spyware/Firewalls Programmes can I lose?

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I currently have COMODO firewall, Lavasoft Ad-Aware and AVG Anti Virus running on my PC but I think it's slowing it down a fair bit. Can I afford to drop one of these and if so which one?

The most visibly active one seems to be COMODO so I preferably want to keep that. I also have Malware Bytes Anti Malware, Spybot and SuperAntiSpyware but none of these are set to automatically start upon booting anymore.
 
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