I run it with everything checked, textures set to medium (everything else high), 4xaa, 16xaf @ 1280x800 and it's great (crap in the benchmark but 25-50fps in game). It's fine at 1280x1024 too but it makes the game look a bit squished and weird for some reason (maybe to do with my scaling settings or something). Also try the latest 163.71 drivers they did wonders for performance in my case.