Sequential box is fantastic but then dont forget you are going to be using a clutch designed to be operated by hand with your foot.
You won't use the clutch when going up the box. Only on the way down.
Bike engines are much more highly strung than car engines. They need their oil changing more frequently and their throttle bodies synching regularly.
A bike engined kit car will me more work to keep in a nice state of tune than a car engined one IMO.
However, I think a bike engine will give more of a racer feel with the screaming revs.