Khan, a fighter who has been knocked down from sturdy punches in the past but recovered, goes straight forward for a toe-to-toe with a much taller, heavy handed Colombian. Yes, Khan was over-matched last night but Khan is a swift and classy fighter who chose not to use his range, speed and timing to get out of this guys way in the first 4 rounds.
Khan called it a "stupid little mistake" but I'd go as far to say it was an amateurs mistake and I honestly don't know how he expected to win with this gameplan. A good technician will nullify Prescott's power as Khan should have done. We know Khan is a slick fighter and could have made a fight of this even if the ending was inevitable.
So, Khan can't take a punch. To be fair to him, Prescott was huge and his record suggests he hits very hard and looking at those clips I'd imagine Prescott could do that to a lot of top fighters. Psychologically, I think we're going to see a gun-shy Khan from now on, another Audley if you like and with Hatton and Calzaghe winding down, there's only Haye left.