I have 6 partitions accross 4 disks...... but there is a purpose.
I have an 80GB SATA2 drive partitioned in half to make a 40GB XP drive and a currently empty 40GB drive for any other OS I decide to install.
I then have a 320GB SATA2 drive labeled 'Data' that has all my data stored on it. My Documents folder maps there, along with all my downloads
I then have a 500GB SATA2 drive. This is partitoned into a 300GB 'Entertainment ' drive that contains all my games installs, and the rest is a 200GB 'Backup' partition that contains a backup of all the important information on my Data drive (My Documents, etc)
The final drive is a 120GB external 2.5" USB drive that is labeled Media, that contains all my Music, and anythign I like to tranport around. This drive is also backed up onto the Backup drive.
Ideally the Backup drive should be its own drive, but space needs forced me to shuffle around. If I run out of space ill get a new one to take the backup.
Having my OS on a totally seperate HDD means if it fails, all i loose is my Windows install, which takes me an hour and a half to install using an nlite disk. Also, if any of the other drives fail I dont loose my OS, so my PC is still fully functional. If either the Data or Media drive fails (my original Media one did) then there is a backup on the Backup drive. The Entertainment drive is the only thing not backed, but its all games which can be reinstalled if needed. The only issue there is saves which im reluctant to worry about. Its the toss up between loosing some saves, or having to backup 300GB and increasing of games data.
But basically, the point is, I have lots of space, without messing about with raid, and any single drive failure is no big issue. There is also no issue with running OS and apps on different drives.