I kind of did it when I come here to Prague.
I made my mind up in a month or so a handful of months after finishing uni, was just working in a rubbish fast food place and thought "what the hell". I found a pretty cruddy job working for an outsourced call centre, after a few months I got off the calling floor and into a behind the scenes job which although it got me off the phones had it's own problems. After about a year and a half in that place I landed a great job this summer which is enjoyable, fulfiling, pays quite well (for the CR) and I have a great boss and workmates.
I'll admit that I came here mainly for a girl like many expats here do but it's been almost 2 years now and it's getting better every day.
There are negative spells which even now I get where I wish I was home, these are mainly language, bureaucracy and food based and only last a few hours.
Food is the biggest problem for me, as an example I got a recipe book for xmas of simple recipes, a recipe that took my fancy was something that required coriander leaves and thai fish sauce which you'd never find in the local supermarkets. There are some specialist Asian food shops that sell that kind of thing but they are half way across the city which is a pain. Things for other recipes are Gruyere and mascarpone cheese, now I don't know for sure if they will be in the supermarket when I check but I don't hold high hopes, they are considered exotic here, even peanut butter is in the "foreign foods" section of Tesco
