For me, Starcraft 2, Mafia 2, Machinarium (click!) and WIC: Soviet Assault (I'm assuming that's penned in for release this year. But I'm going to make a concious effort to ignore the hype this year, so anything decent will come as a pleasant surprise.
Edit: Oh and Zeno Clash! And what the Fraggle Rock: A Starfox game for the PC?1!!?!
"Storm of War:Battle of Britain""
LOL!!!!! Vaporware, the Duke Nuke Em with wings!!!
Deus Ex 3. Enough said.