Well I don't know what's out first, but I'm looking forward to:
Uncharted 2 (kind of disappointed I never got the first one, but I'll get it a couple of weeks before U2 comes out)
Assassin's Creed 2 (despite the first being repetitive, there was some good gameplay there)
Gran Turismo 5
R&C:Crack in Time (big fan of the series since the first one)
MAG (well duh)
And plenty of others, but I'm sure they're even further into 2010.
I would say COD6, but I don't want to get hyped up because I know it'll be a letdown. Hopefully they'll keep some form of the zombies mode from COD5, because that's my favourite part, and probably the only online part of COD worth playing, IMO.