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2x480 you should be able to use more eyecandy then the 295s because of the Vram.
check with someone else though as im not that sure.
GTX 295 = 1,792mb
GTX 480 = 1,536mb
GTX 295 Quad SLI = 3,584mb
GTX 480 SLI = 3072mb
How have the 480's got more vram?
I think from looking around you will be looking at a minimum of 1200w on the psu to run a pair of 480s with overclocking, another chap on here with 2 470's was pulling 1kw at full load